Side Effects on the Nervous System

  • Fatigue
  • Dizziness
  • Headache
  • Paresthesia and Muscular Cramps

Possible Side Effects on the Cardiovascular system

  • Bradycardia
  • Postural disorders (occasionally with syncope)
  • Heart failure
  • Palpitation
  • cardiac arrhythmias
  • Raynaud phenomenon
  • Edema and Precordial pain

Betaloc Zok Side EffectsOther CV Side Effects with Betaloc Zok are uncommon, e.g. Deterioration of the heart failure symptoms, cardiogenic shock in patients with acute myocardial infarction, first degree heart block, edema and precordial pain.

In isolated, cases disturbances of cardiac conduction, gangrene in patients with pre-existing severe peripheral circulatory disorders have also been reported.

Betaloc Zok Side Effects (Psychiatry)

  • Depression
  • decreased mental alertness
  • Somnolence or insomnia
  • Nightmares
  • Personality disorder (observed in isolated cases)

Adverse Effects on the Gastrointestinal tract

Occasionally nausea and vomiting, abdominal pain. Rarely diarrhea or constipation. In isolated cases dryness of the mouth, liver-function test abnormalities

Side Effects on Skin

Rarely skin rash (in the form of urticaria, psoriasiform and dystrophic skin lesions). In isolated cases photosensitivity and increased sweating.

Side Effects on Respiratory Organs

Occasionally dyspnea on exertion, bronchospasm, also in patients without a history of obstructive disease. In isolated cases rhinitis has also been observed.

Betalok Zok Side Effects on the Sense Organs

In isolated cases disturbances of vision, dry and/or irritated eye, conjunctivitis, tinnitus.

Detaloc Zok Drug Interactions

  • Patients receiving concomitant treatment with sympathetic ganglion blocking agents; other beta-blockers, or MAO inhibitors should be kept under surveillance.
  • If concomitant treatment with clonidine is to be discontinued, the beta-blocker medication should be withdrawn several days before clonidine.
  • A watch should be kept for possible negative inotropic and chronotropic effects when Betaloc Zok is given together with calcium antagonists and/or antiarrhythmic agents, and especially after intravenous administration of calcium antagonists of the verapamil-type.
  • Beta-blockers may enhance the negative-inotropic and negative-chronotropic effect of antiarrhythmic agents (of the quinidine type and amiodarone).
  • Digitalis glycoside, in association with beta-blockers, may increase atrioventricular conduction time and may induce bradycardia.
  • In patients receiving β-blocker therapy, inhalation anesthetics enhance the cardio depressant effect.
  • Concomitant treatment with indomethacin may decrease the antihypertensive effect of β-blockers.
  • Under certain conditions, when adrenaline is administered to patients treated with β-blockers, cardio-selective β-blockers interfere much less with blood pressure control than non-selective β-blockers.
  • The dosage of oral anti-diabetics may have to be readjusted in patients receiving β-blockers.
  • Betaloc ZOK may reduce the clearance of other drugs (e.g. lignocaine).

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