Tramadol Side Effects that may occur after administration of the drug resemble those known to occur with other drugs that belong to the opioid group. Tramadol Side Effects shown below were recorded in 13,802 patients from trials with different formulations of this drug. Take a look over the chart below to better understand the rate of incidence of each side effect associated with Tramadol.

Tramadol Side Effects

Tramal Side Effects on Cardiac System

Tramal Side Effects on Vascular System

  • Uncommon
    Orthostatic dysregulation (tendency to collapse and cardiovascular collapse)

Tramal Side Effects on the Respiratory System

  • Rare:
    Dyspnea, Respiratory Depression especially when the recommended doses are considerably exceeded and/or other respiratory depressant substances are administered concomitantly)
  • Very Rare:
    Worsening of asthma (causality not established)

Tramadol Side Effects on Gastrointestinal System

  • Very common:
  • Common:
    Vomiting, Constipation
  • Uncommon:
    Dyspepsia, Diarrhea, Abdominal Pain, Flatulence, Urge to vomit

Metabolism and Nutrition Related Side Effects

Side Effects on the Hepatobiliary System

  • Very rare:
    Elevated Liver Enzymes

Tramadol Side Effects on the Nervous System

  • Very common:
  • Common:
    Autonomic Nervous Effects e.g. Dry Mouth, Perspiration, Headache, Sedation & Asthenia
  • Uncommon:
  • Rare:
    Speech Disorders, Paresthesia, Coordination Disturbance, Tremor, Seizures, Involuntary Muscle Contractions, Syncope.

Psychiatric Disorders Associated with Tramadol Administration

  • Rare:
    Hallucinations, Confusion, Sleep Disturbance, Delirium, Anxiety, Nightmares, Changes In Mood e.g. Euphoric Mood, Occasionally Dysphoria, Changes In Activity e.g. Suppression, Occasionally Increase, Changes In Cognitive And Sensorial Capacity e.g. decision behavior, perception disorders.

Musculoskeletal and Connective Tissue Related Side Effects

  • Rare:
    Motor System Weakness

Tramadol Side Effects on the Endocrine System

Tramadol has some very rare side effects on the endocrine system including syndrome of inappropriate antidiuretic hormone secretion characterized by hyponatremia secondary to decreased free-water excretion.

Possible Effects on Skin and Subcutaneous Tissue

  • Common:
  • Uncommon:
    Skin Reactions, Pruritus, Rash

Tramadol Side Effects on the Immune System

  • Rare:
    Shock Reactions, Anaphylaxis, Allergic Reactions

Effects on the Renal & Urinary System

Tramadol Side Effects on Eyes

Some of the side effects of Tramadol discussed above, e.g. Dizziness, Perspiration, Cardiovascular Collapse, Tachycardia, Nausea and vomiting can be increased with rapid intravenous administration of the drug. A carefully administered, Slow I.V. can greatly help minimize these Tramadol Side Effects.