Enalapril Maleate has been demonstrated to be generally well tolerated. In clinical studies, the overall incidence of side effects was no greater with Enalapril Maleate than with placebo. For the most part, Enalapril Maleate side effects have been mild and transient in nature, and have not required discontinuation of therapy.
The following side effects have been associated with the use of Enalapril Maleate.
Dizziness and headache were the more commonly reported side effects. Fatigue and asthenia were reported in 2-3% of patients. Other Enalapril Maleate side effects that occurred in less than 2% of patients included hypotension, orthostatic hypotension, syncope, nausea, diarrhea, muscle cramps, rash, and cough. Less frequently renal dysfunction and renal failure have been reported.
Angioneurotic edema of the face, extremities, lips, tongue, glottis and / or larynx has also been reported rarely.
Side effects, which occurred very rarely, either during controlled clinical trials or after the drug was marketed are as under;
Enalapril Maleate – Cardiovascular Side Effects
Myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients. Other cardiovascular side effects of Enalapril Maleate include chest pain, palpitations, rhythm disturbances, angina pectoris and raynaud’s phenomenon.
Enalapril Maleate – Gastro-lnstetinal Side Effects
- Hepatic failure
- Hepatitis – either hepatocellular or cholestatic
- Abdominal pain
- Vomiting, Dypepsia, Heartburn, Constipatin, Anoreixa and stomatitis.
Psychiatric & Nervous system related Side Effects
- Vertigo and dream abnormality
Enalapril Maleate – Respiratory Side Effects
- Pulmonary infiltrates
- Bronchospasm /asthma
- Dyspnea, rhinorrhea, sore throat and hoarseness
Enalapril Maleate Side Effects on Skin
- Erythema multiforme
- exfoliative dermatitis
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Pemphigus, puritus, urticaria and atopeica.
Other Side Effects of Enalapril Maleate
A symptom complex has been reported which may include some or all of the following: fever, serositis, vasculitis, myalgia / myositis, arthralgia / arthritis, a Positive ANA, elevated ESR, eosinophilia, and leukocytosis. Rash, photosensitivity or other dermatologic manifestations may also occur with the usage of Enalapril Maleate.