Danzen (Serratiopeptidase), is a proteolytic enzyme developed in the Research and Development division of Takeda Chemical Industries Ltd., Japan. Danzen has high enzyme activities including potent anti-inflammatory, anti-tumefacient, bradykinin decomposing, mucolytic and fibrinolytic actions.
- Danzen Tablets
Each enteric coated tablet contains:
Serratiopeptidase (Takeda) — 5 mg (10,000 Serratiopeptidase units)
- Danzen DS Tablets
Each enteric coated tablet contains:
Serratiopeptidase (Takeda) — 10 mg (20,000 Serratiopeptidase units)
- Intense Fibrinolytic Action
Danzen (Serratiopeptidase) Strongly lyzes fibrin and fibrinogen but does not appreciably affects proteins in the living body such as albumin.
- Potent Bradykinin Decomposing Activity
Danzen (Serratiopeptidase) alleviates pain by inhibiting the release of specific pain-inducing amines known as bradykinin.
- Elimination of Inflammatory Edema
Danzen (Serratiopeptidase) inhibits inflammatory edema by improving the aggravated circulation in the inflammatory focus through breakdown of abnormal exudates and proteins thereby promoting the absorption of the decomposed products in the blood and lymph vessels.
- Acceleration of Liquefaction and Elimination of Sputum, Pus and Hematoma
Danzen (Serratiopeptidase) accelerates the elimination of sputum, pus and hematoma by breaking down and liquefying mucous secretions and fibrin clots.
- Enhancing Effect on the Transfer of Antibiotics to the Focal Site
Danzen (Serratiopeptidase) increases the concentration of antibiotics at the site of infection.
Danzen – Pharmacokinetics
After oral administration, the peak concentration in the blood and lymph was attained less than one hour after administration. The total amount of substance absorbed in the blood and lymph was achieved 6 hours after administration and increase is dose-dependent.
Danzen (Serratiopeptidase) is indicated for the treatment of the following inflammatory conditions:
Surgery: Post-operative edema and hematoma, remission of swelling after surgical stitching, resolution of tissue drainage, ease in post anesthetic sputum expectoration.
Otorhinolaryngology: Acute & chronic sinusitis, Otitis Media, Acute Tonsillitis, Laryngitis, Pharyngitis, Rhinopharyngitis, Inflammation of Eustachian tube, Post Nasal Drip, Nasal Obstruction.
Obstetrics and Gynecology: Mastopathy, Galactostasis Adnexitis, Salpingitis, Lateral episiotomy, Perineal laceration.
Orthopedics: Rheumatoid and Osteoarthritis, Orthopedic Surgery, Bone Fracture, Tendonitis, Ecchymosis, Sprains.
Dentistry and Oral Surgery: Inflammation of Gums, Periodontosis, Alveolar Abscess, Alveolar Fracture and Tooth Fracture after Exodontia, Surgery of the Buccal Area.
Pneumology: Bronchitis, Bronchiectasis, Difficulty of expectoration in Bronchitis. Pulmonary tuberculosis and Bronchial Asthma inadequate expectoration of sputum after anesthesia.
Danzen Dosage and Administration
- Danzen Tablets, 5mg
Usually given for adults in a dose of 1 to 2 tablets orally, three times daily before or after each meal. Dose may be increased depending on the severity of the disease or as prescribed by the physician.
- Danzen DS Tablets 10mg
Usually given for adults in a dose of 1 tablet orally, three times daily before or after each meal. Dose may be increased depending on the severity of the disease or as prescribed by the physician.
Danzen Side Effects
Danzen (Serratiopeptidase) is generally well tolerated. The range of Danzen side effects observed are as follows:
- Hypersensitivity reactions such as redness or rashes, which may infrequently occur.
- Gastrointestinal side effects e.g. Diarrhea, Anorexia, Gastric discomfort, nausea or vomiting may occur infrequently
Danzen Drug Interaction
Danzen (Serratiopeptidase) may intensify the effect of anticoagulants when administered concomitantly, therefore Danzen (Serratiopeptidase) should be given with caution to those patients who take anticoagulants or having blood coagulation abnormalities.
Danzen tablets should be administered with caution to the following patients:
- Patients with blood coagulation disorder
- Patients with serious hepatic or renal disorder
- Chronic Toxicity
Danzen Tablets showed no chronic toxicity when given several times higher than usual human dose to rats when given for 6 months.
- Acute Toxicity
Danzen (Serratiopeptidase) has Ld50 over 2000 mg/kg which is several thousand times higher than usual dose.
- Teratogenic effects
Danzen (Serratiopeptidase) showed no teratogenic effect in experimental animals when given several times higher than usual human dose.
Can Danzen help to shrink Fibroids if consume regularly.
Can Danzen help to relieve Plantar Fasciitis and shrink Fibroids.
Any side effect if consume regularly.
Looking forward to your reply. Thanks.