Myonal (Eperisone Hcl) exhibits both skeletal muscle relaxant and vasodilator properties due to its actions within the central nervous system (CNS) and on vascular smooth muscle. Myonal has an established therapeutic value in improving various symptoms associated with myotonia by interrupting a vicious circle of skeletal muscle.
How Myonal Works?
Myonal acts primarily at the spinal cord level to depress spinal reflexes and produces skeletal muscle relaxation by diminishing the sensitivity of muscle spindles via the Gamma motor neuron system. Moreover, its vasodilatory action enhances the circulation. Thus, Myonal interrupts, in a multifaceted manner a vicious circle that muscle spasm initiates disturbances of blood flow which, in turn, produces pain, leading to further increased muscle tone.
Consequently, Myonal is effective at multiple sites in disrupting the vicious cycle of myotonia (myotonia > circulatory insufficiency > pain > exacerbated myotonia).
Myonal has been proven to be clinically effective in improving symptoms of spasticity and myotonia such as shoulder stiffness, cervical pain, headache, low back pain and muscle contraction rigidity and stiffness of limbs, which may accompany neck-shoulder-arm syndrome, scapulohumeral periarthritis, low back pain or encephalomyelopathies.
What is Myonal Used For?
Myonal Tablets are primarily used to improve conditions caused by;
- Neck-Shoulder-Arm syndrome
- Scapulohumeral Periarthritis
- Myonal is also very effective in the treatment of low back pain spastic paralysis caused by Cerebrovascular disorders, cervical spondylosis, spastic sapinal paralysis, sequelae to trauma e.g. spinal injury, head injury etc., postoperative sequelae including cerebrospinal tumor, amyotrophic lateral sclerosis, cerebral infantile palsy, spinal vascular disorders, subacute myelo-optico neuropathy, spinocerebellar degeneration and other encephalomyelopathies.
The Recommended Dosage of Myonal Tablets
The usual dose of Myonal for adults is 3 tablets in 24 hours. The dose can be adjusted depending on the patient’s age and symptoms. However, it is recommended to take Myonal Tablets in three equally divided doses every day.
Side Effects of Myonal
General side effects of Eperisone Hcl include weakness, light-headed feeling and generalized fatigability. Dizziness or muscle hypotonia, etc., may occur rarely. In some individuals, hot flushes or diaphoresis or edema have also been reported.
Shock , Rash and Pruritus may occur rarely, patients taking Myonal Tablets should be carefully observed, and if any abnormality is observed, therapy should be discontinued and appropriate treatment should be performed.
Hepatic Side Effects
Elavation of GOT, GPT etc., may occur rarely. Therefore, patients should be carefully monitored. If any abnormality is observed, appropriate measures, including discontinuation of Myonal, should be taken.
Renal Side Effects
Proteinuria or elevation of BUN, etc., may occur rarely. Therefore, patients should be carefully monitored. If any abnormality is observed, appropriate measures, including discontinuation of the medication, should be taken.
Hematologic Side Effects
Anemia, etc., may occur rarely. Therefore, patients should be carefully monitored. If any abnormality is observed, appropriate measures, including discontinuation of the medication, should be taken.
Psychoneurologic Side Effects
Insomnia, headache, sleepiness or numbness in the extremities may occur infrequently, and stiffness or trembling in the extremities etc., may occur rarely.
Gastrointestinal Side Effects
Nausea and vomiting, anorexia, stomach discomfort, thirst, constipation, diarrhea or abdominal pain may occur infrequently. Abdomen enlarged feeling or stomatitis, etc., may occur rarely.
Urinary Side Effects
Urinary retention, urinary incontinence, feeling of residual urine or other symptoms of urinary disorders may occur rarely.
Myonal during Pregnancy and Lactation
Safety of Myonal in pregnant women has not been established. Therefore, this medication should only be used in pregnant women or women suspected of being pregnant, provided that the expected therapeutic benefits are evaluated to outweigh the possible risk of treatment.
Myonal is not recommended for women during lactation. If use during lactation is necessary, the patient should avoid breast-feeding during treatment with Myonal.