• Explat 75 Tablet Contains
    Clopidogrel 75mg

Explat 75 mg Tablets

 

What is Explat 75 Used For?

Explat is indicated for the reduction of atherothrombotic events as follows:

  • Recent MI, Recent Stroke or Established Peripheral Arterial Disease
    For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Explat has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.
  • Acute Coronary Syndrome
    For patients with acute coronary syndrome (unstable angina / non-Q-wave MI), including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or CABG, Explat has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI, or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.

How Explat Tablet Works?

Explat is an inhibitor of platelet aggregation. A variety of drugs that inhibit platelet function have been shown to decrease morbid events in people with established atherosclerotic cardiovascular disease as evidenced by stroke or transient ischemic attacks, myocardial infarction, or need for bypass or angioplasty. This indicates that platelets participate in the initiation and/or evolution of these events and that inhibiting them can reduce the event rate.

Administration of Explat Tablets with meals doesn’t significantly modify the bioavailability of Explat as assessed by the pharmacokinetics of the main circulating metabolite.

Recommended Dosage of Explat Tablets

In cases of Recent MI, Recent Stroke, or Established Peripheral Arterial Disease, The recommended daily dose of Explat is 75 mg once daily.

For Patients with acute coronary syndrome, Explat should be initiated with a single 300 mg loading dose and then continued at 75 mg once daily.

When to avoid Explat Tablets?

The use of Explat is contraindicated for individuals with hypersensitivity to clopidogrel or any component of the product. Patients with Active pathological bleeding such as peptic ulcer or intracranial hemorrhage should also avoid Explat.

Explat Tablets should be used during pregnancy only if clearly needed.

Possible Side Effects of Explat Tablets

The most common side effects of Explat are nausea, vomiting, and diarrhea. The incidence of blood dyscrasias is lower with Explat. Rare cases of thrombotic thrombocytopenic purpura have been associated with Explat, these usually remit when the drug is stopped.

Side effects reported in clinical trials include;

  • Pruritus
  • Purpura
  • Diarrhea
  • Rash
  • Neutropenia (decrease in white blood cells) is about 0.1%

Do not take Explat or any other prescription drug without asking a qualified healthcare professional.