Muscoril Capsule & Injection

Muscoril Capsule contains
Thiocolchicoside 4mg
Muscoril Injection contains
Thiocolchicoside 4mg

Muscoril Indications & Recommended Dosage

Muscoril capsules and injections are used as an adjuvant treatment of painful muscle contractures in acute spinal pathology.

For oral use: The recommended and maximal dose of Muscoril is 8 mg every 12 hours (i.e. 16 mg per day). The treatment duration is limited to 7 consecutive days.

For IM use: The recommended and maximal dose of Muscoril Injection is 4 mg every 12 hours (i.e. 8 mg per day). The treatment duration is limited to 5 consecutive days.

Applies To Oral And IM Forms: Doses exceeding recommended doses or long-term use should be avoided. Moreover, Muscoril is not recommended for use in children below the age of 16 years.

When to avoid Muscoril? > Contraindications

Known hypersensitivity to thiocolchicoside or to any excipients in the formulation
Pregnancy and Lactation
In women of childbearing potential who are not using effective contraception.

Special Drug Warnings

Applies To The Oral And IM Forms
In preclinical studies, one of Muscoril (thiocolchicoside) metabolites (SL59.0955) induced aneuploidy (i.e. unequal number of chromosomes in dividing cells) at concentrations close to human exposure observed at doses 8mg twice daily per os. Aneuploidy is reported as a risk factor for teratogenicity, embryofetotoxicity/spontaneous abortion, cancer, and impaired male fertility. As a precautionary measure, use of the product at doses exceeding the recommended dose or long-term use should be avoided.
Post-marketing cases of cytolytic and cholestatic hepatitis have been reported with Muscoril. Severe cases (i.e. fulminant hepatitis) have been reported in patients concomitantly taking NSAIDs or Paracetamol. Patients should be advised to report any sign of liver toxicity.
Muscoril may precipitate seizures, especially in patients with epilepsy or those at risk for seizures.
Patients should be carefully informed about the potential risk of a possible pregnancy and about effective contraception measures to be followed.
Applies to formulations containing lactose/saccharose only: Due to the presence of lactose, patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Due to the presence of saccharose, patients with rare hereditary problems of fructose intolerance should not take Muscoril.

In case of diarrhea the treatment with Muscoril should be stopped. When using Muscoril Injections, cases of syncope vasovagal have been observed and therefore, the patient should be monitored after the injection.

Muscoril during Pregnancy and Lactation

Studies conducted in animals have shown a reproductive toxicity including teratogenic effects. There are insufficient clinical data to evaluate safety of use in pregnancy. Thus, the potential hazards for the embryo and fetus are unknown. In consequence, Muscoril is contraindicated in pregnancy and women of childbearing potential who are not using effective contraception. Moreover, since it passes into the mother’s milk, the use of Muscoril is contraindicated during breastfeeding.

Driving a Vehicle or Performing Other Hazardous Tasks after Taking Muscoril

There are no data available of the effect on driving vehicles and using machines. Clinical studies concluded that Muscoril has no effect on the psychomotor performance. However, somnolence may occur commonly, this has to be taken into account when driving vehicles and operating machines.

2 Comments

fatma at - Reply

for somnolence side effect of muscoril ; what we can do?
I have used Muscoril for 7 days intramuscular

I barely feel my legs and arms even do not feel headache
what can I do?
Giuseppe Melecci at - Reply

Muscoril is also available in capsules of 4 and 8 mg strength. I had several surgical operations in the legs, severe lower back pain in the right buttock. I have never had any problem with muscoril 4 mg/capsules ro witht the 8 mg capsules, but I do not use it for long period (I use for no longer than 5-7 days). I also take Xanax (alprazolam) dihydrocodeine and tramadol..which works well with muscoril

Opioids such as dihydrocodeine are not well tolerated by my body…
Perhaps you have been taking muscoril in injection for too long. Muscoril de-contracts skeletal muscles (which are not under our conscious minds), therefore excessive and protracted doses of muscoril can weaken them. It is a sort of muscle paraliser.
Further: in our lower back the spinal nerves are not inside the spinal chord but they are scattered outside with a shape which is similar to the shape of a horse's tail when it runs. In Human it is called cauda equina (from Latin Horse's tail)

The irritation of the nerve's endings in the lumbar -sacral area can cause pain in the tight muscles, in the buttock, in the lower back, and cause frontal and back loss of sphincters' control, especially when the person affected passes from a lying position to sitting one or from a sitting position to a standing one.

The loss of sensitivity in the legs can be also attributed to either vascular leg impairment of arterial or venous nature, and/or circulation problem in the pelvis area.

I just had several surgical interventions at St Thoases's in London in my leg and groin (embolectionies + fasciotomy) , in spite of the fact that , over a period of 10 years I asked my GP, for a Doppler scan both in the legs and groin, after an inguinal cyst, larger than a chicken egg was detected by a MRI in my right inguinal side.
Has you GP done some instrumental investigation such Doppler scan of the legs and a pelvis ultrasound scan.
These tests are not invasive nor painful , and they measure the blood flow. Also they are quick to do.
All the best,
Giuseppe Meleci

PS
Please fell free to reply to me should you have further questions.